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KI2056TG 1008011 g$2548

Chemical Characteristic

Product NameTG 100801
SynonymsN/A
CAS No.867331-82-6
Molecular Weight 580.08
FormulaC33H30ClN5O3
Chemical Name4-chloro-3-(5-methyl-3-((4-(2-(1-pyrrolidinyl)ethoxy)phenyl)amino)-1,2,4-benzotriazin-7-yl)phenol 1-benzoate
Smilesc1(cc(c(cc1)Cl)c1cc(c2nc(nnc2c1)Nc1ccc(cc1)OCCN1CCCC1)C)OC(=O)c1ccccc1
Chemical Structure

Biological activities

TG 100801 is a VEGFR2 targeting prodrug currently in a clinical trial. The active form is TG100572. TG 100801 is topically applied for the treatment of age-related macular degeneration (AMD). TG 100801 works on kinases that are involved in the VEGF signaling pathway. TG 100801 inhibits downstream VEGF activation of endothelial cells and blocks the effect of VEGF on receptors.[1]

References

[1] http://www.ksos.in/ksosjournal/journalmain/Journal_06-2009.pdf#page=62

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