Thiazovivin Inhibitor CAS No. 1226056-71-8

Cat. No.	Name	Size	Price
KI1235	Thiazovivin	5 mg	$192
	Thiazovivin	10 mg	$336
	Thiazovivin	50 mg	$1072

Chemical Characteristic

Product Name	Thiazovivin
Synonyms	Tzv
CAS No.	1226056-71-8
Molecular Weight	311.36
Formula	C₁₅H₁₃N₅OS
Chemical Name	N-(Phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide
Smiles	s1c(nc(c1)C(=O)NCc1ccccc1)Nc1ncncc1
Chemical Structure

Biological activities

Thiazovivin is a novel ROCK inhibitor with an IC50 value of about 0.6 µM. Thiazovivin significantly increases hESC survival after dissociation while maintaining characteristic hESC colony morphology and alkaline phosphatase (ALP) expression. Thiazovivin enhances hESCs -ECM adhesion-mediated β1 integrin signaling, which synergizes with growth factors to promote cell survival. Thiazovivin also protects hESCs in the absence of ECM by regulating E-cadherin-mediated cell-cell interaction. In addition, thiazovivin treatment significantly blocks endocytosis of E-cadherin, resulting in stabilizing E-cadherin and leading to reestablishment of cell-cell interaction, which is essential for hESC survival in ECM-free conditions. Furthermore, thiazovivin, at the concentration of 2 µM, inhibits ROCK activity and protects hESCs at a similar level as Y-27632 at the concentration of 10 µM.^[1] Treatment with thiazovivin allows porcine embryonic fibroblasts (PEFs) to directly convert to fat-laden adipocytes.^[2] Thiazovivin (1 µM) increases the reprogramming efficiency of CB cells to induced pluripotent stem cells (iPSCs) by more than 10 times.^[3]

Protocols

In vitro: Thiazovivin is dissolved in DMSO.^[1]

References

[1] Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A. 2010, 107(18): 8129-8134. [2] Zhu J, et al. Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules. Cell Reprogram. 2012, 14(2): 99-105. [3] Hu K, et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011, 117(14): e109-119.

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