Thiotepa Inhibitor CAS No. 52-24-4

Cat. No.	Name	Size	Price	Add Cart
KI1001	Thiotepa	1 g	$300

Chemical Characteristic

Product Name	Thiotepa
Synonyms	Thioplex
CAS No.	52-24-4
Molecular Weight	189.22
Formula	C₆H₁₂N₃PS
Chemical Name	Tris(1-aziridinyl)phosphine sulfide
Smiles	S=P(N1CC1)(N1CC1)N1CC1
Chemical Structure

Biological activities

Thiotepa is an alkylating agent used to treat cancer. Thiotepa has been used in the palliation of a wide variety of neoplastic diseases and used as intravesical chemotherapy in bladder cancer. Thiotepa is metabolized in human liver microsomes by CYP3A4 (major) and CYP2B6 (minor).^[1] In vitro chemosensitivity studies, plasma levels of the thiotepa 's primary metabolite, TEPA, is sufficient to induce significant cell kills in all three tumour lines derived from three histologically different murine colon tumours (MAC).^[2] With human bladder cancer cells in culture, cytotoxicity of thiotepa is increased up to 10-fold by posttreatment with pentoxifylline. Furthermore, with human bladder or breast cancer xenografts in a modified subrenal capsule assay, enhancement of thiotepa is also observed by in vivo posttreatment with pentoxifylline.^[3]

Protocols

In vivo: Thiotepa is dissolved in 0.9% NaCl solution.^[3]

References

[1] Jacobson PA, et al. Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol. 2002, (6): 461-467. [2] Phillips RM, et al. Experimental correlations of in vitro drug sensitivity with in vivo responses to ThioTEPA in a panel of murine colon tumours. Cancer Chemother Pharmacol. 1988, 21(2): 168-172. [3] Fingert HJ, et al. In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa. Cancer Res. 1988, 48(15): 4375-4381.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com