Thorazine Inhibitor CAS No. 50-53-3

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KI0661	Thorazine	Quote	Quote

Chemical Characteristic

Product Name	Thorazine
Synonyms	Chlorpromazine,Largactil, Megaphen
CAS No.	50-53-3
Molecular Weight	318.86
Formula	C₁₇H₁₉ClN₂S
Chemical Structure

Biological activities

Thorazine is a dopamine receptor antagonist. Thorazine possesses additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties. Thorazine belongs to the typical antipsychotic class of medications. Thorazine is used to treat schizophrenia. Thorazine inhibits CaM with an IC50 of 2.75 µM.^[1] Thorazine induces inflammatory reaction.^[2] In the dog, thorazine is metabolized almost completely but, partly because of its extensive localization in various tissues, especially brain, relatively slowly.^[3] Thorazine significantly opposes ketamine dose-dependently reduced prepulse inhibition (PPI).^[4]

Protocols

Thorazine is dissolved in physiological saline.^[5]

References

[1] Martinez-Luis et al. Malbrancheamide, a new calmodulin inhibitor from the fungus Malbranchea aurantiaca. Tetrahedron. 2006, 62(8): 1817-1822. 閵嗏偓閵嗏偓 [2] Cohen, et al. Episkin: An in vitro model for the evaluation of phototoxicity and sunscreen photoprotective properties. Toxicology in Vitro. 1994, 8(4): 669-671. 閵嗏偓閵嗏偓 [3] BRODIE BB, et al. Physiological disposition and fate of chlorpromazine and a method for its estimation in biological material. J Pharmacol Exp Ther. 1956, 118(1): 46-54. 閵嗏偓閵嗏偓 [4] Swerdlow NR, et al. Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats. Psychopharmacology (Berl). 1998, 140(1): 75-80. 閵嗏偓閵嗏偓

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