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Cat. No. Name Size Price Add Cart
KI0763Tianeptine sodium salt10 mg$180
Tianeptine sodium salt50 mg$600

Chemical Characteristic

Product NameTianeptine sodium salt
SynonymsStablon, Coaxil, Tatinol
CAS No.30123-17-2
Molecular Weight 458.93
FormulaC21H24ClN2NaO4S
Chemical NameSodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide
Smiles[Na] C(=O)(CCCCCCNC1c2c(N(S(=O)(=O)c3c1ccc(c3)Cl)C)cccc2)O
Chemical Structure

Biological activities

Tianeptine sodium salt is the sodium salt form of tianeptine. Tianeptine is a stimulator of 5-hydroxytryptamine (5-HT) uptake. Tianeptine has antidepressant effect. Tianeptine (1, 10 and 100 µM) inhibits lactate dehydrogenase (LDH) release from cortical neuronal cultures as efficiently as the N-methyl-D-aspartate (NMDA) antagonist, MK-801. Tianeptine does not block apoptosis in cultured cortical neurones caused by NMDA, but reduces apoptosis when interleukin-1β(IL-1β) is included with NMDA.[1] Tianeptine (10 mg/kg) significantly reduces both the expression of serotonin transporter mRNA and serotonin transporter binding sites labeled by [3H]paroxetine in rat dorsal raphe nucleus.[2] Ex vivo, after subchronic treatment (10 mg/kg/day i.p.) in rats, tianeptine induces an increase (30%) in [14C]serotonin uptake at a [14C]serotonin concentration of 500 nM while clomipramine induces a decrease (40%) in [14C]serotonin uptake.[3] Tianeptine (10 mg/kg) exhibits a significant antinociceptive activity in mice.[4] Furthermore, tianeptine delays the onset time of pentylenetetrazole (PTZ)-induced seizure via adenosine A1 receptors in mice.[5]

Protocols

In vivo: Tianeptine is dissolved in 0.9% saline.[5]

References

[1] Plaisant F, et al. Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology. 2003, 44(6): 801-809.
[2] Kuroda Y, et al. Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain. Eur J Pharmacol. 1994, 268(1): R3-5.
[3] Kato G, et al. Neurochemical profile of tianeptine, a new antidepressant drug. Clin Neuropharmacol. 1988, 11 Suppl 2:S43-50.
[4] Uzbay IT, et al. Analgesic effect of tianeptine in mice. Life Sci. 1999, 64(15): 1313-1319.
[5] Uzbay TI, et al. Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors. Neuropsychopharmacology. 2007, 32(2): 412-416.

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