Tranilast Inhibitor CAS No. 53902-12-8

Cat. No.	Name	Size	Price	Add Cart
KI0720	Tranilast	50 mg	$192

Chemical Characteristic

Product Name	Tranilast
Synonyms	Rizaben
CAS No.	53902-12-8
Molecular Weight	327.34
Formula	C₁₈H₁₇NO₅
Chemical Structure

Biological activities

Tranilast is an antiallergic agent. Tranilast inhibits chemical mediator release from mast cells. Tranilast inhibits the proliferation and vascular endothelium growth factor (VEGF)-induced chemotaxis of human dermal microvascular endothelial cells (HDMECs) with IC50 values of 136 and 135 µM , respectively. Tranilast inhibits tube formation of HDMECs cultured on the matrigel as an in vitro angiogenesis model in a concentration-dependent manner.^[1] In vitro, tranilast restores cytokine (such as interleukin-1 β, tumor necrosis factor-α, and lipopolysaccharide)-induced nitric oxide production against platelet-derived growth factor in vascular smooth muscle cells.^[2] In cultured human skin fibroblasts in vitro, tranilast also inhibits collagen synthesis in a dose-dependent manner to a maximum of 55% at 300 µM during 48 hours of treatment.^[3] In vivo angiogenesis in mice, tranilast treatment (0-300 mg/kg) dose-dependently suppresses angiogenesis in the matrigel.^[1] In vivo, tranilast also suppresses the content of collagen in granulation tissue of hypersensitive granulomatous inflammation induced by methylated bovine serum albumin (m-BSA) in rats.^[4]

Protocols

In vivo: Tranilast is dissolved in 0.5% carboxymethyl cellulose-Na.^[1]

References

[1] Isaji M, et al. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br J Pharmacol. 1997, 122(6): 1061-1066. [2] Hishikawa K, et al. Tranilast restores cytokine-induced nitric oxide production against platelet-derived growth factor in vascular smooth muscle cells. J Cardiovasc Pharmacol. 1996, 28(2): 200-207. [3] Yamada H, et al. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem. 1994, 116(4): 892-897. 閵嗏偓閵嗏偓 [4] Isaji M, et al. Inhibition by tranilast of collagen accumulation in hypersensitive granulomatous inflammation in vivo and of morphological changes and functions of fibroblasts in vitro. Life Sci. 1994, 55(15): PL287-292. 閵嗏偓閵嗏偓

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