Trilostane Inhibitor CAS No. 13647-35-3

Cat. No.	Name	Size	Price
KI1042	Trilostane	10 mg	$160
	Trilostane	25 mg	$288
	Trilostane	100 mg	$1088

Chemical Characteristic

Product Name	Trilostane
CAS No.	13647-35-3
Molecular Weight	329.43
Formula	C₂₀H₂₇NO₃
Chemical Name	(4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Smiles	C1(=O)[C@@H](C[C@]2([C@@]3(C1O3)CC[C@H]1[C@@H]3CC[C@@H]([C@@]3(C)CC[C@H]21)O)C)C#N
Chemical Structure

Biological activities

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase with an IC50 value of 1 µM.^[1] Trilostane is used in the treatment of Cushing's syndrome. In vitro fertilization, trilostane (1-0.1 µM) causes low normal pronuclear formation and high polyspermy.^[2] In vitro, trilostane inhibits conversion of pregnenolone to progesterone but does not alter conversion of cholesterol to pregnenolone nor progesterone to corticoid hormones. When given orally to rats, trilostane inhibits corticosterone and aldosterone production and elevates circulating levels of pregnenolone at doses lower than those that produce adrenal hypertrophy or inhibit gonadal steroidogenesis.^[1] In addition, the intracerebroventricular infusion of 0.3 µg/hour trilostane effectively blocks the increase in systolic blood pressure and reverses the hypertension produced by drinking 0.9% saline in both female and male rats.^[3]

Protocols

In vitro: Trilostane is dissolved in DMSO.^[4]

References

[1] Potts GO, et al. Trilostane, an orally active inhibitor of steroid biosynthesis. Steroids. 1978, 32(2): 257-267. [2] Suzuki S, et al. Biological effects of trilostane in vitro on oocyte maturation and fertilization in the hamster. Experientia. 1984, 40(11): 1214-1217. [3] Gomez-Sanchez EP, et al. Effect of 3beta-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol. 2005, 288(2): R389-393. [4] Nagata Y, et al. Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev. 2003, 17(23): 2864-2869.

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