Cat. No. Name Size Price Add Cart
KI1479Uramustine250 mg$180
Uramustine1 g$600

Chemical Characteristic

Product NameUramustine
CAS No.66-75-1
Molecular Weight 252.1
FormulaC8H11Cl2N3O2
Chemical Name5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Smilesc1(=O)[nH]c(=O)c(c[nH]1)N(CCCl)CCCl
Chemical Structure
DocumentsHNMR CNMR HPLC MS

Biological activities

Uramustine is a chemotherapy drug which belongs to the class of alkylating agents. The IC50 value of uramustine against human leukemia K562 line is 5.1 µM.[1]Uramustine is used in lymphatic malignancies such as non-Hodgkin's lymphoma. Uramustine leads to apoptosis of cancer cells by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division.

References

[1] Viegas-Junior C, et al. Molecular hybridization: a useful tool in the design of new drug prototypes. Curr Med Chem. 2007, 14(17): 1829-1852.

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