Ursodiol Inhibitor CAS No. 128-13-2

Cat. No.	Name	Size	Price	Add Cart
KI0816	Ursodiol	5 mg	$272
KI0816	Ursodiol	50 mg	$950

Chemical Characteristic

Product Name	Ursodiol
Synonyms	Actigall, Ursodeoxycholic acid
CAS No.	128-13-2
Molecular Weight	392.57
Formula	C₂₄H₄₀O₄
Chemical Structure

Biological activities

Ursodiol is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Ursodiol is cytoprotective and has beneficial effect on the bile acid pool in the liver. In vitro, ursodiol at concentrations of 5, 25 and 50 µM inhibits the proliferation of human peripheral blood mononuclear cells in a dose-dependent manner. Ursodiol also decreases interleukin-2 production and inhibits the proliferation of the interleukin-2-dependent cell line CTLL-2.^[1] In a mouse model of experimental colonic carcinoma, ursodiol inhibits the development of colon cancer.^[2] In addition, supplemental dietary ursodiol (0.2% or 0.4%) is a chemopreventive agent in the azoxymethane (AOM) model of experimental colonic carcinogenesis.^[3] In the AOM model of Male CD-1mice, ursodiol treatment (0.016%, 0.08%, or 0.4%) significantly inhibits the multiplicity of colonic adenocarcinoma. Ursodiol treatment also significantly lowers the proliferating cell nuclear antigen labeling index in the colonic malignancies. Ursodiol feeding reduces the expression of inducible nitric oxide synthase and tumor necrosis factor-α mRNA in the colonic mucosa.^[4]

References

[1] Lacaille F, et al. The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology. 1993, 18(1): 165-172. 閵嗏偓閵嗏偓 [2] Kim HS, et al. Prevention of colon cancer with ursodiol in ulcerative colitis. Inflamm Bowel Dis. 2001, 7(3): 279-280. 閵嗏偓閵嗏偓 [3] Earnest DL, et al. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 1994, 54(19): 5071-5074. [4] Kohno H, et al. Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. Clin Cancer Res. 2007, 13(8): 2519-2525. 閵嗏偓閵嗏偓

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