VE-822 Inhibitor CAS No. 1232416-25-9

Cat. No.	Name	Size	Price
KI2743	VE-822	5 mg	$148
	VE-822	10 mg	$234
	VE-822	25 mg	$470
	VE-822	50 mg	$752
	VE-822	100 mg	$1202

Chemical Characteristic

Product Name	VE-822
CAS No.	1232416-25-9
Molecular Weight	463.55
Formula	C₂₄H₂₅N₅O₃S
Chemical Name	3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine
Smiles	c1(c(nc(cn1)c1ccc(cc1)S(=O)(=O)C(C)C)c1onc(c1)c1ccc(cc1)CNC)N
Chemical Structure
Documents	HPLC COA MS

Biological activities

VE-822 is a highly selective and potent derivative of ATR inhibitor. In vitro and in vivo, VE-822 abrogates cell cycle checkpoints, enhances persistence of residual DNA damage and blocks homologous recombination repair.^[1] Furthermore, VE-822 decreases survival of pancreatic cancer cells but not normal cells in response to XRT or gemcitabine. In vivo, in an abdominal irradiation murine model, VE-822 prolongs growth delay of pancreatic cancer xenografts after XRT and gemcitabine-based chemoradiation without augmenting normal cell or tissue toxicity.^[2]

Protocols

In vitro, VE-822 is dissolved in DMSO. While in vivo studies, VE-822 is dissolved in 10% Vitamin E d-alpha tocopheryl polyethylene glycol 1000 succinate and administered by gavage, in 200 mL.^[1][2]

References

[1] Fokas E, et al. Targeting ATR in DNA damage response and cancer therapeutics. Cancer Treat Rev. 2014. 40 (1): 109-117 [2] Fokas E, et al. PMC3542617Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. Cell Death Dis. 2012, 3(12): e441.

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