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Cat. No. Name Size Price Add Cart
KI0818Verteporfin10 mg$512
Verteporfin50 mg$1552
Verteporfin100 mg$2672

Chemical Characteristic

Product NameVerteporfin
SynonymsVisudyne
CAS No.129497-78-5
Molecular Weight 718.79
FormulaC41H42N4O8
Chemical Structure

Biological activities

Verteporfin is a benzoporphyrin derivative. Verteporfin is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels. In vitro, cytotoxic effect of photodynamic therapy using verteporfin (2 µg/mL) can be augmented by paclitaxel in gastric cancer cells (NCI-N87) and bile duct cancer cells (YGIC-6B).[1] A panel of pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, PANC-1 and Capan-2) have gemcitabine non-responsive populations (17 to 33%) at doses up to 1mM while moderate total verteporfin photodynamic therapy (PDT) doses (1閳?µMJ/cm2) produce nearly complete killing. Verteporfin-based PDT also decreases Bcl-XL and increases the bax/Bcl-XL ratio toward a pro-apoptotic balance.[2] In vivo, verteporfin incorporated into small nanoparticles effectively controls tumor growth for 20 days in mice with early light irradiation times following verteporfin administration.[3]

Protocols

In vivo: Verteporfin is dissolved in dimethyl sulfoxide (DMSO) or 5% dextrose solution.[4]

References

[1] Park S, et al. Paclitaxel augments cytotoxic effect of photodynamic therapy using verteporfin in gastric and bile duct cancer cells. Photochem Photobiol Sci. 2008, 7(7): 769-774. 閵嗏偓閵嗏偓
[2] Celli JP, et al. Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines. Lasers Surg Med. 2011, 43(7): 565-574. 閵嗏偓閵嗏偓
[3] Konan-Kouakou YN, et al. In vitro and in vivo activities of verteporfin-loaded nanoparticles. J Control Release. 2005, 103(1): 83-91. 閵嗏偓閵嗏偓
[4] Ota J, et al. Local photodynamic therapy for equine squamous cell carcinoma: evaluation of a novel treatment method in a murine model. Vet J. 2008, 176(2): 170-176. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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