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Cat. No. Name Size Price Add Cart
KI0667Vidarabine50 mg$154

Chemical Characteristic

Product NameVidarabine
SynonymsVIRA-A, adenine arabinoside, arabinosyladenine
CAS No.5536-17-4
Molecular Weight 267.24
FormulaC10H13N5O4
Chemical Structure

Biological activities

Vidarabine is a purine nucleotide analog that inhibits viral DNA synthesis. The IC50 of vidarabine against herpes simplex virus (HSV)-1, HSV-2, phosphonoacetic acid (PAA)-resistant HSV-1 and thymidine kinase (TK)-deficient HSV-1 is 9.3, 11.3, 21.1 and 14.1 µM, respectively.[1] Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine exhibits good activity in cell culture against two small pox related viruses (vaccinia and cowpox) with EC50 of 6.2 and 12.6 µM, respectively. [2] Vidarabine is a synthetic purine nucleoside with antiviral activity against a broad group of DNA-containing viruses and some RNA tumour viruses. [3] Vidarabine dose-dependently inhibits viral replication as assessed by a yield reduction assay. [4] Vidarabine is also active against vaccinia virus in vivo. [2]

Protocols

Vidarabine is dissolved at 10 mg/mL in DMSO. [4]

References

[1] Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006, 72(2): 157-161. 閵嗏偓閵嗏偓
[2] Shen W, et al. Design and synthesis of vidarabine prodrugs as antiviral agents. Bioorg Med Chem Lett. 2009, 19(3): 792-796. 閵嗏偓閵嗏偓
[3] Chadwick RG, et al. HBsAg-positive chronic liver disease: inhibition of DNA polymerase activity by vidarabine. Br Med J. 1978, 2(6136): 531-533. 閵嗏偓
[4] Kurosaki K, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004, 15(5): 281-285. 閵嗏偓閵嗏偓

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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