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KI1347Vincristine50 mg$432

Chemical Characteristic

Product NameVincristine
CAS No.57-22-7
Molecular Weight 824.96
FormulaC46H56N4O10
Chemical Name[3aR-[3a?,4?,5?,5a?,9(3R*,5S*,7R*,9S*),10bR*,13a?]]- 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1
Smilesc1ccc2c(c1)c1c([nH]2)[C@@](C[C@H]2CN(CC1)C[C@](C2)(O)CC)(C(=O)OC)c1c(cc2c(c1)[C@@]13[C@@H](N2C)[C@@]([C@@H]([C@]2([C@@H]1N(CC=C2)CC3)CC)OC(=O)C)(O)C(=O)OC)OC OS(=O)(=O)O
Chemical Structure

Biological activities

Vinblastine is a vinca alkaloid that is firstly found from the plant periwinkle Catharanthus roseus. Vinblastine has been widely used as antitumor agents for the treatment of leukemias, lymphomas, and some solid tumors. Vinblastine can induce the destabilization of polymerized tubulin, by binding to a site recently localized on β-tubulin, and have a high affinity for the protein.[1] Vinblastine interferes with cell mitosis by promoting the depolymerization of spindle fiber microtubules. In addition, vinblastine has been demonstrated to inhibit nicotinic acetylcholine receptor (nAChR) activity in adrenal chromaffin cells and superior cervical ganglia and to alter agonist binding affinity to nAChR of the electric organ of torpedo californica. Vinblastine inhibits nAChR-stimulated catecholamine release with an IC50 of 8.9µM. Vinblastine (10-200µM) produces an increase in baseline tension of diaphragm muscle. [2]

Protocols

Vinblastine is dissolved in a physiologic salt solution containing 2 mM Ca2+ and 0.5% bovine serum albumin in vitro assay. [2]

References

[1] Jordan A, et al. Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998, 18 (4): 259-296.
[2] Mckay DB, et al. Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993, 203 (3): 372-376.

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