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Cat. No. Name Size Price Add Cart
KI1375Vinorelbine TartrateQuoteQuote

Chemical Characteristic

Product NameVinorelbine Tartrate
SynonymsNavelbine, KW-2307
CAS No.125317-39-7
Molecular Weight 1079.11
FormulaC45H54N4O8.2C4H6O6
Chemical Name3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
Smilesc1(c(cc2c(c1)[C@@]13C(N2C)[C@@]([C@@H]([C@]2(C1N(CC=C2)CC3)CC)OC(=O)C)(O)C(=O)OC)OC)[C@]1(CC2C=C(CN(C2)Cc2c3c([nH]c12)cccc3)CC)C(=O)OC OC(=O)[C@@H]([C@H](C(=O)O)O)O OC(=O)[C@@H]([C@H](C(=O)O)O)O
Chemical Structure

Biological activities

Vinorelbine tartrate is a semisynthetic vinca alkaloid drug. Vinorelbine tartrate inhibits G361 and StMll la with the mean IC50 of 19.9 and 26.9 nM, respectively. In StMll la, vinorelbine tartrate (1 nM, 24 hours exposure) induces intense areas of staining mainly in the peripheral area of the cytoplasm, likely to be bundling of tubulin.[1] Vinorelbine tartrate inhibits PC-12 cell growth at slightly lower concentration than vindesine at the short exposure time of 1-8 hours. The combination of vinorelbine tartrate with cisplatin decreases the cell number rapidly, indicating that both combination regimens are rational. [2] Vinorelbine tartrate inhibits bladder carcinoma cell line (J82) and resistance factor of the resistant subline (J82-NVB) with IC50 of 0.20 and 3.44 µM, respectively. Vinorelbine tartrate is mitotic inhibitor and has been used as antitumor chemotherapeutic drug with a broad spectrum and strong activity. [3]

Protocols

Vinorelbin tartrate is diluted to 1 mM in PBS and 1% DMSO in vitro assay. [1]

References

[1] Photiou A, et al. In vitro synergy of paclitaxel (Taxol) and vinorelbine (navelbine) against human melanoma cell lines. Eur J Cancer. 1997, 33(3): 463-470.
[2] Debal V, et al. Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids. Br J Cancer. 1994, 70(6): 1118-1125.
[3] Gomi K, et al. Kinetic analysis of combination effect of navelbine (KW-2307) with cisplatin against human lung adenocarcinoma PC-12 cells in culture. Jpn J Cancer Res. 1992, 83(5): 532-539.

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