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Cat. No. Name Size Price Add Cart
KI3754VU036173710 mg$154
VU036173750 mg$630

Chemical Characteristic

Product NameVU0361737
CAS No.1161205-04-4
Molecular Weight 263
FormulaC13H11CIN2O2
Chemical NameN-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Smilesc1(ccccn1)C(=O)Nc1cc(c(cc1)Cl)OC
Chemical Structure

Biological activities

VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors respectively. It can nactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors, also can penetrate into CNS [1,2].

References

[1] Engers DW, Niswender CM, Weaver CD, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009, 52(14):4115-4118.
[2] Mologni L, Rostagno R, Brussolo S, et al .Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J Med Chem. 2011, 54(4): 1106??110.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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