Cat. No. Name Size Price Add Cart
KI2406VU036443910 mg$234
VU036443950 mg$752

Chemical Characteristic

Product NameVU0364439
CAS No.1246086-78-1
Molecular Weight 422.29
FormulaC18H13Cl2N3O3S
Chemical NameN-[3-chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
Smilesc1(ccccn1)C(=O)Nc1cc(c(cc1)S(=O)(=O)Nc1c(cccc1)Cl)Cl
Chemical Structure

Biological activities

VU0364439 is a potent mGlu4 positive allosteric modulators (PAMs). The EC50 of VU0364439 is 19.8 nM. VU0364439 possess excellent in vitro potency, but possess less than ideal PK properties preventing the use as in vivo tools.[1]

References

[1] Engers DW, et al. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg Med Chem Lett. 2010, 20(17): 5175-5178.

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