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Cat. No. Name Size Price Add Cart
KI1461WIN 51711QuoteQuote

Chemical Characteristic

Product NameWIN 51711
SynonymsDisoxaril
CAS No.87495-31-6
Molecular Weight 342.43
FormulaC20H26N2O3
Smileso1nc(cc1CCCCCCCOc1ccc(cc1)C1=NCCO1)C
Chemical Structure

Biological activities

WIN 51711 is a potent inhibitor of human entero- and rhinoviruses. The MIC50 of WIN 51711 is ranging from 0.004 to 6.2 µg/mL against 9 enteroviruses and 33 rhinoviruses including poliovirus type 2, MEF strain.[1] WIN 51711 maintains the viral RNA in the encapsidated state after penetrating the cell membrane.[2] WIN 51711 completely inhibits the arrival of viral RNA in the cytoplasm for new RNA synthesis only when the inocula are preincubated with WIN 51711 for 15 minutes at 37°C at 0.3 µg/mL for poliovirus type 1 and 0.03 µg/mL for poliovirus type 2. WIN 51711 inhibits the replication of polioviruses types 1 and 2 in HeLa cells by stabilizing the virus capsid, which results in the inhibition of the pH-dependent viral uncoating in endosomes and/or lysosomes. [3] WIN 51711 reduces the titers of virus in asymptomatic mice on day 6 after infection compared with placebo.[4]

Protocols

In vitro: WIN 51711 is dissolved in DMSO.[5]

References

[1] Otto MJ, et al. In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.Antimicrob Agents Chemother. 1985, 27(6): 883-886.
[2] Fox MP, et al. Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug.Antimicrob Agents Chemother. 1986, 30(1): 110-116.
[3] Zeichhardt H, et al. Inhibition of poliovirus uncoating by disoxaril (WIN 51711). Virology. 1987, 160(1): 281-285.
[4] McKinlay MA, et al. Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice. J Infect Dis. 1986, 154(4): 676-681.
[5] Mosser AG, et al. Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions. J Virol. 1994, 68(12): 8193-8201.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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