Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI2375Wnt-C59 (C59)5 mg$396
Wnt-C59 (C59)50 mg$2032

Chemical Characteristic

Product NameWnt-C59 (C59)
SynonymsN/A
CAS No.1243243-89-1
Molecular Weight 379.45
FormulaC25H21N3O
Chemical Name4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
Smilesc1(ccc(cc1)c1cc(ncc1)C)CC(=O)Nc1ccc(cc1)c1cnccc1
Chemical Structure

Biological activities

Wnt-C59 is a potent and selective Wnt signaling antagonist with an IC50 less than 0.11 nM.[1] Wnt-C59 is a potent inhibitor of porcupine (PORCN). Wnt-C59 inhibits Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with an IC50 of 0.074 nM.[2] Wnt-C59 prevents palmitylation of Wnt proteins by PORCN, thereby blocking Wnt secretion and activity. Wnt-C59 blocks fibronectin-mediated migration and invasion in MDA-MB231 cells.[1] Wnt-C59 blocks progression of mammary tumors in MMTV-Wnt1 transgenic mice while down-regulating Wnt/?-catenin target genes.[2]

Protocols

In vivo, Wnt-C59 is resuspended by sonication for 20 minutes in a mixture of 0.5% methylcellulose and 0.1% Tween-80.[2]

References

[1] Dey N, et al. Wnt signaling in triple negative breast cancer is associated with metastasis. BMC Cancer. 2013, 13(1): 537.
[2] Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013, 73(2): 502-507.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook