WYE-354 Inhibitor CAS No. 1062169-56-5

Cat. No.	Name	Size	Price
KI0542	WYE-354	5 mg	$192
	WYE-354	10 mg	$220
	WYE-354	50 mg	$880

Chemical Characteristic

Product Name	WYE-354
CAS No.	1062169-56-5
Molecular Weight	495.53
Formula	C₂₄H₂₉N₇O₅
Chemical Name	4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester
Smiles	N1(CCC(CC1)n1c2nc(nc(c2cn1)N1CCOCC1)c1ccc(cc1)NC(=O)OC)C(=O)OC
Chemical Structure

Biological activities

WYE-354 is a potent and ATP-competitive inhibitor of mTOR. The IC50 value of WYE-354 against mTOR is 5 nM. WYE-354 dose dependently inhibits mTORC2-specific substrate His6-AKT or the mTORC1 substrate His6-S6K. WYE-687 profoundly inhibits cap-dependent and global protein synthesis in human breast cancer cell line MDA361. WYE-354 also induces a small but significant amount of PARP cleavage in the PTEN-null LNCap cells but not in HCT116 or HT29 cells. WYE-354 shows antiproliferative effects in MDA361 and U87MG cells involving G1 cell cycle arrest and selective induction of apoptosis. WYE-354 down-regulates angiogenic factors.^[1] In vitro, WYE-354 also induces phosphorylation and inactivation of the translation elongation factor eEF2 in MDA361 cells.^[2] When injected into tumor-bearing mice, WYE-354 inhibits mTORC1 and mTORC2 and displays robust antitumor activity in PTEN-null tumors. In vivo, WYE-354 treatment (50 mg/kg ) achieves dose-dependent suppression of tumor growth.^[1]

References

[1] Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009, 69(15): 6232-6240. [2] Shor B, et al. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle. 2009, 8(23): 3831-3837.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.

KareBay^TM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.

About

KareBay^TM Biochem
Sitemap
Blog

Custom Services

Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services

Biochemical Products

Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR

KareBay^TM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852

Telephone

: 732-823-1545

Fax

: 732-823-1349

product@karebaybio.com
service@karebaybio.com
support@karebaybio.com