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Cat. No. Name Size Price Add Cart
KI0545WYE-6875 mg$374
WYE-68710 mg$592
WYE-68750 mg$1620
WYE-687200 mg$3000

Chemical Characteristic

Product NameWYE-687
CAS No.1062161-90-3
Molecular Weight 528.61
FormulaC28H32N8O3
Chemical NameN-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester
SmilesC(=O)(Nc1ccc(cc1)c1nc2c(c(n1)N1CCOCC1)cnn2C1CCN(CC1)Cc1cnccc1)OC
Chemical Structure

Biological activities

WYE-687 is a potent and ATP-competitive inhibitor of mTOR. The IC50 value of WYE-687 against mTOR is 7 nM. WYE-687 dose dependently inhibits mTORC2-specific substrate His6-AKT or the mTORC1 substrate His6-S6K. WYE-687 profoundly inhibits cap-dependent and global protein synthesis in human breast cancer cell line MDA361. WYE-687 also shows antiproliferative effects in MDA361 and U87MG cells involving G1 cell cycle arrest and selective induction of apoptosis. WYE-687 down-regulates angiogenic factors.[1] In vitro, WYE-687 also induces phosphorylation and inactivation of the translation elongation factor eEF2 in MDA361 cells.[2]

References

[1] Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009, 69(15): 6232-6240.
[2] Shor B, et al. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle. 2009, 8(23): 3831-3837.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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