Home
Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassay Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
Polymers & Contract Manufacturing
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Products
Small Molecule Inhibitors and Antagonist
Bioactive Compounds and Agonist
Primary Antibodies
Catalog Peptides
Amino Acids Derivatives
Reagents
Fluorescent dyes
Intermediates
PCR
Proteasomes and Enzymes
Enzyme substrate
Nucleotides
Promotions
Customer Support
About Us
Site Map
Contact Us
Small Molecule Inhibitors and Antagonist
Anti-virus
Cell Cycle
DMPK/Tox
Endocrinology
Epigenetics
GPCR/G-protein
Mitogen-activated Protein Kinases (MAPK)
PI3K/Akt/mTOR
Proteases/Proteasome
Protein Tyrosine Kinases (PTK)
Stem Cells
TGF-Beta/Smad
Transporter
Others
Cat. No. Name Size Price Add Cart
KI0315YM1555 mg$112
YM15510 mg$180
YM15525 mg$300
YM155100 mg$1000

Chemical Characteristic

Product NameYM155
CAS No.781661-94-7
Molecular Weight 443.29
FormulaC20H19BrN4O3
Chemical Name1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)
Smilesc1(n(c2c(n1Cc1cnccn1)C(=O)c1ccccc1C2=O)CCOC)C Br
Chemical Structure

Biological activities

YM155 is a novel small-molecule surviving suppressant and potently inhibits surviving promoter with an IC50 value of 0.54 nM.[1] YM155 specifically inhibits the expression of survivin at both the mRNA and protein levels with little effect on expression levels of other IAP family or Bcl-2-related proteins. An advantage of YM155 compared with previously investigated suppressors of survivin expression is that it is active in the subnanomolar range. YM155 suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM. [1] YM155 elicits cytotoxicity on glioblastoma cells with IC50s of 30-35 nM. [2] Besides that, YM155 also inhibits the survival of H460 cells with IC50 of 64 nM , Calu6 cells with IC50 of 43 nM. [3] Meanwhile, YM155 inhibits the growth of 119 human cancer cell lines, with the greatest activity in lines from non-Hodgkin?? lymphoma, hormone-refractory prostate cancer, ovarian cancer, sarcoma, non-small-cell lung cancer, breast cancer, leukemia and melanoma with the mean log growth inhibition of 50% (GI50) value of 15 nM, the mean GI50 values of YM155 are 11 nM for p53 mut/null cell lines and 16 nM for p53 WT cell lines. In the NCI-H358 xenograft model, YM155 displays superior anticancer activity to that of cisplatin or paclitaxel at highly tolerable dosage levels. [4]

Protocols

YM155 at a concentration of 0-50 nM is dissolved in DMSO and incubated for 48 hours.[2]

References

[1] Lai PC, et al. Novel Survivin Inhibitor YM155 elicits Cytotoxicity in Glioblastoma Cell Lines with Normal or Deficiency DNA-Dependent Protein Kinase Activity. Pediatr Neonatol. 2012, 53(3): 199-204.
[2] Takahito N, et al. YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts. Cancer Res. 2007, 67: 8014-8021.
[3] Tsutomu L, et al. Radiosensitizing Effect ofY M155, a Novel Small-Molecule Survivin Suppressant, in Non Small Cell Lung Cancer Cell Lines. Cancer Res. 2008, 14: 6496-6504.
[4] Takahito N, et al. Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models. Cancer Sci. 2011, 102(3): 614-621.

Please click here to fill online order form, and we will make sure to supply you product with detail information. This process usually takes between 24 to 48 hours, depending on products stock avaliability. All inquires and subsequent projects are handled in the strictest confidence and will be backed by a confidentiality agreement if required.
KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
About
KareBayTM Biochem
Sitemap
Blog
Custom Services
Organic Synthesis
Peptide Synthesis
Antibody Production
Protein Expression
Bioconjugation Service
Immunoassry Service
Molecular Biology Services
Oligonucleotides Synthesis
RNA Synthesis Service
cGMP Peptide Synthesis Services
cGMP Organic Synthesis Services
Biochemical Products
Small Molecule Inhibitors
Bioactive Compounds
Primary Antibodies
Peptides
Amino Acids
Reagents
Fluorescent dyes
Intermediates
PCR
Contact Us
KareBayTM Biochem, Inc.
11 Deer Park Drive, Suite 102A
Monmouth Junction, NJ 08852
Telephone
: 732-823-1545

Fax
: 732-823-1349
product@karebaybio.com
service@karebaybio.com
support@karebaybio.com
Follow Us
Follow Karebay on LinkedinFollow IMAGING on Twitter Google+ Facebook