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Cat. No. Name Size Price Add Cart
KI0886Ziprasidone10 mg$112
Ziprasidone50 mg$272

Chemical Characteristic

Product NameZiprasidone
SynonymsGeodon, Zeldox
CAS No.122883-93-6
Molecular Weight 449.4
FormulaC21H21ClN4OS.HCl
Chemical Structure

Biological activities

Ziprasidone is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C and 5-HT7 receptors antagonist. The Ki of ziprasidone is 3.4, 4, 2.3, 0.4, 1.3 and 6 nM against 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C and 5-HT7, respectively. In addition, the Ki of ziprasidone is 4.8, 7.2 and 32 nM, against D2 receptor, D3 receptor and D4 receptors, respectively. Ziprasidone is a widely used atypical antipsychotic drug. Mild concentrations of ziprasidone improve the in vitro proliferation of hippocampal-derived neural stem cells (NSCs) and increase the levels of pERK1/2 and Bcl-2 in NSCs.[1] The administration of ziprasidone significantly attenuates the immobilization stress-induced decrease in BDNF mRNA expression in the rat hippocampus and neocortex. Ziprasidone reveals differential effects on BDNF mRNA expression in the rat hippocampus and neocortex.[2] Ziprasidone attenuates the neuronal apoptosis which occurs in the hippocampus. Ziprasidone reverses the anxiety-like behaviors in rats that exposed to an enhanced single prolonged stress paradigm. Ziprasidone restores the proliferation and the protein expression of pERK1/2 and Bcl-2 in the hippocampus of these rats. [1] Acute ziprasidone at the dose of 2.5 mg/kg produces a significant attenuation of the impairment induced by sub-chronic phencyclidine in the reversal phase.[3]

Protocols

In vivo: Ziprasidone is dissolved in distilled water.[3]

References

[1] Peng Z, et al. Ziprasidone ameliorates anxiety-like behaviors in a rat model of PTSD and up-regulates neurogenesis in the hippocampus and hippocampus-derived neural stem cells. Behav Brain Res. 2013, S0166: 4328. 閵嗏偓閵嗏偓
[2] Park SW, et al. Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats. J Psychiatr Res. 2009, 43(3): 274-281. 閵嗏偓閵嗏偓
[3] Snigdha S, et al. Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation. Behav Brain Res. 2008, 187(2): 489-494. 閵嗏偓閵嗏偓

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