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Cat. No. Name Size Price Add Cart
KI3685ZM30641610 mg$250
ZM30641650 mg$1000

Chemical Characteristic

Product NameZM306416
CAS No.690206-97-4
Molecular Weight 333.74
FormulaC16H13ClFN3O2
Chemical NameN-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine
Smilesn1cnc(c2cc(c(cc12)OC)OC)Nc1c(cc(cc1)Cl)F
Chemical Structure

Biological activities

ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 ?M, but also found to inhibit EGFR with IC50 of <10 nM [1]. In vitro, ZM-306416 induces selective antiproliferative effect toward the EGFR-addicted NSCLC cell lines H3255 and HCC4011 with IC50 of 0.09 ?M and 0.072 ?M, respectively. ZM-306416 inhibits granule formation with IC50 of 0.67 ?M. [1] ZM-306416 significantly inhibits the ERR? assay with IC50 of 7.3 ?M in the GeneBLAzer T-Rex ROR?-UAS-bla HEK293T cell line. [2]

References

[1]. Han SY, Park SS, Lee WG, et al. Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006,16(1):129-133.
[2]. Antczak C, Mahida JP, Bhinder B, ea al. A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012,17(7):885-899.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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