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Cat. No. Name Size Price Add Cart
KI1317Zoledronic acid25 mg$112
Zoledronic acid100 mg$336

Chemical Characteristic

Product NameZoledronic acid
SynonymsZometa
CAS No.118072-93-8
Molecular Weight 290.1
FormulaC5H12N2O8P2
Chemical NamePhosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-
SmilesC(Cn1cncc1)(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure

Biological activities

Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and matrix metalloproteinase-1 (MMP-1) by the tumoral environment. [1] Zoledronate is used for the treatment of multiple myeloma and controlling hypercalcemia in some malignancies and bone metastasis osteolysis. [2] Zoledronate induces both myeloma cell and bone marrow stromal cell (BMSC) apoptosis. Zoledronate significantly inhibits MMP-1 production by BMSCs stimulated with IL-1β more efficiently than pamidronate.[1] Zoledronate has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of prenylation of intracellular proteins. Zoledronate synergizes with R115777 farnesyltransferase inhibitor (FTI) in inducing apoptosis and growth inhibition on epidermoid cancer cells. Zoledronate inhibits human prostate adenocarcinoma cells (PC3, LnCaP, DU145) with IC50 of 13, 18 and 34 µM, respectively. In vivo, zoledronate/R115777 combination induces cooperative effects on tumor growth inhibition of prostate cancer xenografts in nude mice with a significant survival increase. [3]

Protocols

Zoledronate is dissolved in phosphate-buffered saline and stored at ??0 °C until use in vitro. [1]

References

[1] Derenne S, et al. Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and MMP-1 by the tumoral environment. J Bone Miner Res. 1999, 14(12): 2048-2056.
[2] Merigo E, et al. Jaw bone necrosis without previous dental extractions associated with the use of bisphosphonates (pamidronate and zoledronate): a four-case report. J Oral Pathol Med. 2005, 34(10): 613-617.
[3] Caraglia M, et al. R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. J Cell Physiol. 2007, 211(2): 533-543.

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KareBayTM provides scientists and clinicians with a wide range of biotechnological products and science lab supplies for chemical research and analyzing life processes. KareBay's extensive capabilities include commercializing reagents and kits, manufacturing biotech products and providing contract research services to organizations worldwide. Our many global labs, offices, and business partners enable KareBay to extend its products and services to its customer base around the world.

Our products are used for research, laboratory and further evaluation purposes. They are not for human use.
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